PPARα: Energy Combustion, Hypolipidemia, Inflammation and Cancer
نویسندگان
چکیده
منابع مشابه
PPARα: energy combustion, hypolipidemia, inflammation and cancer
The peroxisome proliferator-activated receptor alpha (PPARalpha, or NR1C1) is a nuclear hormone receptor activated by a structurally diverse array of synthetic chemicals known as peroxisome proliferators. Endogenous activation of PPARalpha in liver has also been observed in certain gene knockout mouse models of lipid metabolism, implying the existence of enzymes that either generate (synthesize...
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The epidemic of obesity and its unfortunate sequelae — including, but not limited to, type 2 diabetes, cardiovascular disease and certain cancers — continues to grow. Fortunately, recent discoveries have inspired a veritable gold rush of scientific activity on energy balance in academic and industrial labs alike. As a consequence, we have learned more about the central and peripheral regulation...
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Peroxisome proliferator-activated receptors (PPARs) have lately attracted much attention as therapeutic targets. Previously, PPAR ligands were associated with the treatment of diabetes, hyperlipidemia and cardiovascular diseases, as they modulate the expression of genes regulating glucose and lipid metabolism. Recently, PPAR ligands have been also considered as potential anticancer agents, with...
متن کاملPPARα downregulates airway inflammation induced by lipopolysaccharide in the mouse
BACKGROUND Inflammation is a hallmark of acute lung injury and chronic airway diseases. In chronic airway diseases, it is associated with profound tissue remodeling. Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a ligand-activated transcription factor, that belongs to the nuclear receptor family. Agonists for PPARalpha have been recently shown to reduce lipopolysaccharide (LPS...
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ژورنال
عنوان ژورنال: Nuclear Receptor Signaling
سال: 2010
ISSN: 1550-7629,1550-7629
DOI: 10.1621/nrs.08002